胰岛素抵抗与不孕症相关性研究进展
2024-04-09 17:46
2024.1李维宏研究团队在“Front Endocrinol”杂志上发表题为“胰岛素抵抗与不孕症相关性研究进展”的综述。本文从多角度探讨和阐述了胰岛素抵抗参与生殖过程的不同重要环节和作用机制，胰岛素抵抗影响不孕人群的生殖健康，妊娠结局和子代安全。This is a narrative review of the progress of research on the correlation between insulin resistance and infertility. Insulin resistance (IR) is not only involved in the development of various metabolic diseases, but also affects female reproductive function, and to some extent is closely related to female infertility. IR may increase the risk of female infertility by activating oxidative stress, interfering with energy metabolism, affecting oocyte development, embryo quality and endometrial tolerance, affecting hormone secretion and embryo implantation, as well as affecting assisted conception outcomes in infertile populations and reducing the success rate of assisted reproductive technology treatment in infertile populations. In addition, IR is closely associated with spontaneous abortion, gestational diabetes and other adverse pregnancies, and if not corrected in time, may increase the risk of obesity and metabolic diseases in the offspring in the long term. This article provides a review of the relationship between IR and infertility to provide new ideas for the treatment of infertility.adverse pregnancy outcomes; assisted reproductive technology; infertility; insulin resistance; offspring health.这是一篇关于胰岛素抵抗与不孕的相关性研究进展的叙述性综述。胰岛素抵抗不仅参与各种代谢性疾病的发生发展，而且影响女性的生殖功能，在一定程度上与女性不孕不育密切相关。胰岛素抵抗可能通过激活氧化应激，干扰能量代谢，影响卵母细胞发育，影响胚胎质量和子宫内膜容受性，影响激素分泌和胚胎植入，增加女性不孕的风险，以及影响不孕人群的助孕结局，降低不孕人群辅助生殖技术治疗的成功率。此外，胰岛素抵抗与自然流产、妊娠期糖尿病和其他不良妊娠密切相关，如果不及时纠正，远期可能会增加后代患肥胖症和代谢性疾病的风险。本文综述了胰岛素抵抗与不孕症的关系，为不孕症的治疗提供新的思路。不良妊娠结局；辅助生殖技术；不孕症；胰岛素抵抗；子代健康
